Telomeres and Telomerase Activation in San FranciscoWhat are Telomeres? Telomeres (pronounced tel-uh-meer or tee-luh-meer) are caps at the ends of chromosomes to protect the genes. A portion of the telomeres is lost with each cell division, and the telomeres become shorter as we age. Telomeres may be lengthened by an enzyme called telomerase, but most human cells do not have telomerase. The word telomere is derived from the Greek words "telos," which means 'end' and "meros," which means 'part,' hence, an "end-part." In 2009, the Nobel Prize was awarded to 3 researchers for their work with telomeres and telomerase. With each cell division, the telomeres become shorter and shorter. Eventually, they become too short, and the cell cannot divide normally - then the cell becomes inactive or dies. After that, the cell (or organ) can no longer do its job, leading to aging. For all humans and almost all species, telomeres shorten as we get older. This shortening process is associated with increased risk of heart disease, cancer, and many other diseases of aging. Shorter telomeres are associated with a higher risk of dying at a younger age. Watch Dr. Bartnof present Telomere Effects on Healthspan and Lifespan at the Bio-Identical Hormone Replacement Symposium.
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Through extensive research it is becoming apparent that shorter telomeres contribute to many age-related diseases. In fact, studies show that shorter telomere length is associated with many conditions and diseases in humans, such as:
By measuring the length of telomeres and percentage of short telomeres in a person's body, it is possible to estimate the biologic age (which may be older, younger, or the same as one's actual age). The shorter the length and the greater the number of short telomeres, the more aged a person will be on that marker. Many cumulative factors can contribute to a person aging faster than necessary such as stress, years of depression, exposure to pollutants and chemicals, smoking cigarettes, poor diet, and lack of exercise. For example, depressed people with more than nine years of cumulative lifetime of depression had telomeres that were 281 "base pairs" shorter than the control group in that study. That is equivalent to seven years of accelerated cell aging! Contact Dr. Bartnof for Telomere Testing and TA-65 Programs.Baseline telomere testing measures the average length of your telomeres and indicates the percentage of telomeres that are shorter than average for your age. These tests provide an estimate of your actual biologic age. Another test to inquire about is Immune Cell Subset testing. These tests can indicate whether your immune system has aged faster, with a greater risk for cancer and infections. Immune Subset testing would also indicate whether any of the available Age Management treatments are medically indicated, including supplements to help lengthen your telomeres. If indicated, telomerase activation may be prescribed to safely lengthen your telomeres. Telomerase activation increases the amount of telomerase enzyme produced in your body. The telomerase enzyme helps to extend telomeres by adding back DNA bases at the ends of chromosomes. This allows cells to live longer. The result is that your body's cells are rejuvenated and revert to a more youthful profile. Telomerase activation leading to longer telomeres in published studies of mice is associated with a host of benefits, such as:
In a published study of humans, telomerase activation with a telomerase activator supplement showed:
Lengthen your telomeres and turn back the clock on biologic aging by contacting Dr. Bartnof and the health professionals at California Longevity and Vitality Medical Institute®. With expertise in Telomeres and the advanced science of TA-65 supplementation, Dr. Bartnof strives to help you have a more youthful profile. Be informed; knowledge is power! Know your telomeres! Dr. Harvey S. Bartnof, M.D. is Founder and Medical Director at California Longevity & Vitality Medical Institute® in San Francisco. He is a graduate of University of California at San Francisco School of Medicine where he was on the faculty for 8 years. He has hosted an internet Radioshow, "Age Management Medicine in the 21st Century" on www.voiceamerica.com. Dr. Bartnof is Visiting Professor of Medicine at Liaoning Medical College and Shenyang Medical College in China. He practices full-time Age Management Medicine in San Francisco at his Institute. |
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